Subject: VPHi: upcoming webinars on cardiovascolar modeling (24 Feb - R. Chabiniok) & cardiology and pharmacology (23 Feb - B. Rodriguez)

Dear VPHi members,
in the next days two interesting webinars will take place:

23 Feb 2021 - 15 CET: Avicenna Alliance Member WebinarTopic: Enabling Precision Medicine through the Digital Twin and In Silico Trial,presented by Blanca Rodriguez - University of Oxford

Registration link:

This webinar belongs to the Avicenna Alliance webinar series for members-only, a monthly initiative has the goal to enable both Avicenna member companies and VPHi Members to get to know each other better and share their knowledge about their main activities, expertise and interests.  We kindly invite you not to share this registration link with colleagues who are not VPHi members.

Precision Medicine aims at providing the most accurate diagnosis and best treatments for each patient. Whereas this has primarily been genomic-centred so far, there is now a wide recognition of the need to consider a wide spectrum of lifestyle, environment, and biology conditions. Characterising such diversity of factors requires large quantity and quality of patients’ datasets, and at the same time, innovative approaches for their analysis, drawing on the increasing power of computers and algorithms. New concepts are being proposed, such as the Digital Twin and In Silico Drug Trials. In this presentation, I will address this framework for cardiology and pharmacology, highlighting how combined computational approaches including modelling and simulation, and machine learning can boost the capacity for diagnosis and prognosis, as well as future treatments.


24 Feb 2021 - 16 CET: VPHi Keynote Webinar Series Webinar - Topic: Translational Cardiovascular Modeling: Tetralogy of Fallot & Modeling of Diseases, presented by Radomir Chabiniok - UTSW Medical Center Dallas

Registration link:

This webinar belongs to the VPHi keynote webinar series, a quarterly event organized by the VPHi Student Committee that provides a forum for access to senior community members and their expert competence for chiefly young scientists, but also to the VPH community as a whole. The webinar is open to anyone and free of charge, so you're welcome to distribute to invitation to any of your colleagues who might be interested to attend.

Translational cardiovascular modeling (TCM) combines clinical data with physiologically and biophysically based models of heart, large vessels or circulation, while aiming to contribute to diagnosis (e.g. new or more reliable bioindicators for patient stratification) or optimal clinical management (thanks to predictive capabilities of biophysical models). Increasing the mutual knowledge between clinicians and researchers in TCM is crucial to succeed in advancing the novel methods into the clinical practice and this seminar aims to contribute in facilitating such a multi-disciplinary interaction.

TCM brings the opportunity to address a number of clinical problems not sufficiently solved by current techniques. Models of heart mechanics are applicable during assessing ventricular function at regular follow up exams or planning of intervention (while coupling the models with detailed clinical data), or at perioperative period or acute exacerbation of heart failure (when coupled with signals monitoring cardiovascular physiology at operation theatre or intensive care unit). Electromechanical heart models can contribute to the planning of cardiac resynchronization therapy. Blood flow assessed by combining phase contrast magnetic resonance imaging with a flow model can contribute to the decision about a possible intervention e.g. on heart valves or large vessels. Furthermore, advanced imaging and image processing constrained by biophysical models allow to study distinct patterns, which could be associated with a disease progress.

While the above mentioned TCM methods can serve for a number of acquired or congenital cardiovascular diseases, in this webinar we will demonstrate their applicability on tetralogy of Fallot (TOF). TOF is the most common complex congenital heart disease, in which several TCM techniques can be combined. Most of the results presented in this webinar have been achieved in the clinical-modeling collaborative venture TOFMOD (Tetralogy Of Fallot & Modeling Of Diseases), launched primarily between Inria France and UT Southwestern Medical Center Dallas, with associated partners spanning clinical, imaging and modeling groups over the globe.

Full info on:

If you're interested to attend, please make sure to register asap.
Don't hesitate to contact us if you have any questions.

Best regards

In silico medicine will be the future
Virtual Physiological Human Institute for Integrative Biomedical Research (VPH Institute)

Celestijnenlaan 300C, 3001, Heverlee, Belgium
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