Topical Soy Based Supplement for Dog Allergies
This is part of a fairly recent study- here is a summary of the study:
Heejung Kim, Jong Rhan Kim, Heerim Kang, Jinhwan Choi, Hee Yang, Pomjoo Lee, Jiyoung Kim, and Ki Won Lee: 7,8,4 -Trihydroxyisoflavone Attenuates DNCB-Induced Atopic Dermatitis-Like Symptoms in NC/Nga Mice PLoS One. 2014; 9(8): e104938. Published online Aug 29, 2014. doi: 10.1371/journal.pone.0104938 PMCID: PMC4149428
Atopic dermatitis (AD) is characterized by chronic highly pruritic and relapsing inflammatory skin lesions.
Despite its growing prevalence, therapeutic treatments remain limited.
Natural immune modulators from herbal extracts or derivatives may be useful for treating AD symptoms.
In this study AD-like symptoms were induced on the ear and dorsal skin of mice, then 7,8,4-trihydroxyisoflavone (7,8,4-THIF), a metabolite of soy isoflavone daidzin, was applied topically for 3 weeks and its effects quantified through assessment of skin lesion, dermatitis score, ear thickness and scratching behaviour.
The treatment was found to relieve all quantified symptoms. Furthermore, histologically the treatment was found to reduce eosinophil and mast cell infiltration into skin lesions, significantly alleviated water loss through the epidermal layer, reduced serum IgE and levels of chemokine thymus and activation regulated chemokine, interleukin, cytokines and interferon-y.
The results suggest that 7,8,4-trihydroxyisoflavone may prove to be an effective therapy for atopic dermatitis.
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