Low soil productivity is one of the key challenges limiting maize yields in Ghana. A wide yield gap exists between farm and potential yields across most of the agroecological zones (AEZs) of Ghana. Despite low soil fertility challenges, the low use of fertilizers still predominates the smallholder farming system. To improve crop performance, there is a need for integrated soil fertility management across the AEZs. This calls for site-specific fertilizer recommendations that provide all nutrients in balanced proportions as per the nutrient status of the soil.